Penetrex Joint & Muscle Therapy – Soothing Comfort for Back, Neck, Hands, Feet – Premium Whole Body Rub with Arnica, Vitamin B6 MSM & Boswellia – Non-Greasy 4oz Cream

8 reviews for Penetrex Joint & Muscle Therapy – Soothing Comfort for Back, Neck, Hands, Feet – Premium Whole Body Rub with Arnica, Vitamin B6 MSM & Boswellia – Non-Greasy 4oz Cream

1. 

   Rated 3 out of 5

   Bob J. – 10/12/2025

   Not bad as a pain relieving cream, but far too expensive for me.

2. 

   Rated 5 out of 5

   Sajid patel – 22/12/2025

   My wife backpain fully curred

3. 

   Rated 5 out of 5

   Andrew – 30/12/2025

   I have suffered from RSIs for the past 5 years, and have been using Penetrex regularly for the past 2 years as part of my attempts to treat them. As anyone with RSIs know, these injuries are complex and poorly understood – it marks the beginning of an ongoing journey. In addition to my review of Penetrex, I will share some of my journey – maybe it will help someone else.

   I’ll get right to the point: Does Penetrex have a positive effect, and is that effect worth the money? In my opinion, yes! However, it is no magic bullet. Penetrex is just one of many factors which can affect an injury, and while I have found it decently potent, it will not single-handidly right all wrongs in the RSI universe. If the only change you make in life is to start using Penetrex, it is unfair to poorly rate it if trouble still remains. I think perhaps the abundance of rave reviews could set some people up for disappointment; the rave reviews are completely deserved in my opinion, just remember the context of the person writing it. There are too many unpredictable factors to ensure that Penetrex will be a good fit for absolutely every person. But I would say that your odds are good, and for just $20, it is among the cheapest experiments in treatment you’ll ever make.

   To those who complain about a lack of pain relief from Penetrex – I actually think the focus on pain relief is somewhat misplaced. I have always thought of Penetrex as a healing aid, and in that aspect I am very satisfied with its effectiveness. I have noticed some immediate relief upon application, but for me the difference has been in long-term recovery. You really do need to faithfully use it as directed to reap the maximum benefits. I don’t need so much pain relief these days, as significantly less pain is being generated to begin with – something I am very grateful for. I don’t know how exactly it works, but I’m aware that it does.

   For people with allergies and sensitive skin, I have read of some folks reacting negatively to this cream. Unfortunately, nothing works for everyone. For myself, I have generally troublesome allergies and struggle with psoriasis and eczema. I developed contact dermatitis from using wrist braces, and can’t wear them anymore. But for all the grief my skin gives me, Penetrex has only had positive effects on me. When in doubt, do a patch test.

   I give this product 5 stars because, especially when you consider the cost of other treatments (and I’m not just talking about money), Penetrex delivers great bang for the buck. My experience with it leads me to believe that it is an inherently effective product backed by a reputable company. As I only seem to age in one direction – older – I anticipate being a customer of theirs for quite some time.

   Still struggling with RSIs though? Penetrex is a wonderful start, but most of us probably need more on top of this. Here’s a distilled list of what I have found most effective over my years of struggle. It is these things which mean I am now healing over time instead of getting worse and worse. Maybe some of these suggestions will help you. I hope so! This is not medical advice, so please talk to your doctor before doing anything crazy. Best wishes.

   Alcohol – I could not believe the profound impact that even infrequent drinking had on my RSIs. It took me a long time to realize the correlation even existed. I’ve since quit drinking completely, and have improved significantly off this change alone. The takeaway – the occasional treat may still be punishing you chronically when it comes to what you eat/drink. Be mindful of what you put in your body!

   Trigger point therapy – overuse of muscles can cause them to permanently tense up, shortening the muscles and leading to irritation of the ligaments. Pressure is how you get the muscle fibers to release. I’ve gotten profound relief from this. There are some excellent products on amazon for self-massaging pressure points. It’s been a real game changer for me.

   Exercising underused muscles – Releasing the tense overused muscles is just one side of the coin for me. I also need to exercise opposing muscle groups. For me, the best tool has been the flextend glove, which is available through their website. I was hesitant to buy it because it’s expensive and their website is very ad jargony, but it gets to a point and you’re willing to risk a big chunk of change just on the chance it helps. Well if part of your issue truly is muscle balance, the flextend helps a LOT. But like any exercise, you can hurt yourself using it. You don’t need to go wild with the thing to get results! Workouts will sometimes cause me some irritation in the short term (cue Penetrex), but over the long term it has been very good for me.

   Frequent breaks from irritating activities: You really, really need to step away from your work frequently throughout the day. I use the pomodoro technique – I work for 25 minutes, then break for 5 (get up, move around, stretch). Every 2 hours, it’s a 20 minute break. I use the handy program Focus Booster, which is free, to keep track of my time. This is also a documented technique for improving productivity, so if you have a cool boss, you might be able to sell them on introducing this at your workplace!

   Perfect ergonomics: If prices were bothering you before, you are really going to cry when it comes to this. As an example, I just spent over $600 on a new chair. That’s the low end of the price spectrum you need to be looking in, if you work sitting down. And then there’s the effort aspect – it takes time to habitually develop awareness of posture. But there’s just no way around it – the best way to heal RSIs is to minimize the damage being done to begin with.

   Mechanical keyboard: If you do lots of typing, having a mechanical keyboard in a standard layout is superior to having a non-mechanical keyboard in an “ergonomic” layout. It’s very difficult to find an “ergonomic” mechanical keyboard and they are very expensive. I am not sure if it’s really worth it to go there. I just went with a standard layout and am very happy with it. The Cherry Red switches are the best for RSI sufferers, and you can additionally install red (2mm) or blue (4mm) rubber O rings on the underside of keys to reduce travel distance. Many suppliers will pre-install these for you, though Amazon sells key cap removal tools and the O rings for cheap, if you want to go DIY. I also recommend using a ten-keyless keyboard design unless you really use that numpad – and even then, you might consider a stand-alone numpad. The reduced travel distance between the keyboard and mouse adds up.

   Braces: While I used to swear by my wrist braces, I have grown to develop mixed feelings about them in the long run. I personally think they are best used as a short-term aid. They’re best for when you’re sleeping and during the most aggravating activities of the day, but be sure to give yourself significant “free time” if at all possible. If you’re working with braces on, I think it’s good to view them as a posture training tool more than anything else. Ideally, you should strive to reach a point where you can maintain good position without relying on the brace to enforce it.

   I hope some of this information proved useful to my fellow RSI sufferers! Good luck!!

4. 

   Rated 5 out of 5

   Michelle H – 31/12/2025

   I honestly can’t believe how well this works! I did a workout where I was sore for 5 straight days. The next week, I did the SAME workout, put on this cream before bed, and woke up…not sore. I didn’t trust it, because it seemed like magic, but after going through a whole bottle of this stuff, I’m blown away!

   SECRET TIP: If you put it on the night you worked out, before bed, and don’t wait until you’re ALREADY sore? I find it works even better. Maybe 50% better, in that case? It’s still helpful on already sore muscles, but not as dramatic.

   Why I like this:
   -I have tried Sore No More, Icy Hot, and at least 3 kinds of “hippie balms” with natural ingredients and all that, and most of them burned, felt cold, and then…did nothing. THIS ONE actually moves the needle!
   -It doesn’t burn. So you don’t have to worry about accidentally getting it anywhere, um, sensitive.
   -It doesn’t make you smell like a tube of toothpaste.
   (No noticeable odor at all).
   -It’s thinner, when you get the roll on applicator, so it’s not as thick and sticky to put on. You still need to wait for it to dry for a second before putting fabric on top, but it’s way, way faster than the creams and ointments and doesn’t get all over everything.
   -My husband finds this much more effective for putting on hairy legs, whereas creams and ointments just get all gummed up in the hair and it’s gross.

   I LOVE this stuff and I’ve already gone through a whole tube. Buying a spare for my big horseback riding trip so I can share with friends!

5. 

   Rated 5 out of 5

   DAVID GARLINGE – 09/01/2026

   Easy to use and very effective.

6. 

   Rated 5 out of 5

   Beza. G – 12/01/2026

   Good

7. 

   Rated 5 out of 5

   Cleopatra J. – 16/01/2026

   Excelente Servicio Amable llego antes de lo previsto buena calidad le encantó ya que le ayudo mucho a sus dolores articulares

8. 

   Rated 4 out of 5

   Kelly Evans – 20/01/2026

   I’ve been using this now for 2 weeks, and am downgrading my rating from 5 to 4. I think it may be working somewhat, but after 2 weeks, I’m definitely not dramatically better. I do like having something to rub on there that seems vaguely soothing and may be helpful, but I was hoping for more.

   Also, from the product description online, I thought DMSO was the top ingredient. Looking at DMSO products, many people reported pain relief. And it’s well known that DMSO is effective transdermally, and carries other ingredients through the skin. But it’s also reported to smell fishy. So I figured Penetrex had solved that problem.

   Penetrex does smell fine, but DMSO is pretty far down the list of ingredients on the jar itself. The top ingredient is water, and the next one is Arnica.

   My original review:
   I’ve got acute tennis elbow.

   In searching for how this product could produce the results many are reporting (and a few denying) I came across a helpful passage on this page:[oops, I guess I can’t put the link. I’ll edit to say I just Googled DMSO, and read the top result.]

   I’ll update later with my results. I’m giving it a 5 star rating in anticipation, but will change it if warranted.

   “DMSO Penetrates Membranes and Eases Pain

   The first quality that struck Dr. Jacob about the drug was its ability to pass through membranes, an ability that has been verified by numerous subsequent researchers.1 DMSO’s ability to do this varies proportionally with its strength–up to a 90 percent solution. From 70 percent to 90 percent has been found to be the most effective strength across the skin, and, oddly, performance drops with concentrations higher than 90 percent. Lower concentrations are sufficient to cross other membranes. Thus, 15 percent DMSO will easily penetrate the bladder.2

   In addition, DMSO can carry other drugs with it across membranes. It is more successful ferrying some drugs, such as morphine sulfate, penicillin, steroids, and cortisone, than others, such as insulin. What it will carry depends on the molecular weight, shape, and electrochemistry of the molecules. This property would enable DMSO to act as a new drug delivery system that would lower the risk of infection occurring whenever skin is penetrated.

   DMSO perhaps has been used most widely as a topical analgesic, in a 70 percent DMSO, 30 percent water solution. Laboratory studies suggest that DMSO cuts pain by blocking peripheral nerve C fibers.3 Several clinical trials have demonstrated its effectiveness,4,5 although in one trial, no benefit was found.6 Burns, cuts, and sprains have been treated with DMSO. Relief is reported to be almost immediate, lasting up to 6 hours. A number of sports teams and Olympic athletes have used DMSO, although some have since moved on to other treatment modalities. When administration ceases, so do the effects of the drug.

   Dr. Jacob said at a hearing of the U.S. Senate Subcommittee on Health in 1980, “DMSO is one of the few agents in which effectiveness can be demonstrated before the eyes of the observers….If we have patients appear before the Committee with edematous sprained ankles, the application of DMSO would be followed by objective diminution of swelling within an hour. No other therapeutic modality will do this.”

   Chronic pain patients often have to apply the substance for 6 weeks before a change occurs, but many report relief to a degree they had not been able to obtain from any other source.”